Help for Celiacs and Gluten-Sensitive!

To diagnose celiac disease, several tests are available. Here are the common tests used in the diagnosis of celiac disease:

Serology Tests: These blood tests measure the levels of specific antibodies that are commonly present in individuals with celiac disease. The most commonly used antibodies are tissue transglutaminase antibodies (tTG-IgA) and deamidated gliadin peptide (DGP) antibodies. Elevated levels of these antibodies suggest the possibility of celiac disease.

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Genetic Testing: Genetic testing can determine the presence of certain human leukocyte antigen (HLA) genes associated with celiac disease, particularly HLA-DQ2 and HLA-DQ8. However, having these genes does not necessarily mean a person will develop celiac disease, as many people with these genes do not develop the condition. 

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Intestinal Biopsy: A small intestine biopsy is considered the gold standard for diagnosing celiac disease. During an endoscopy, a small tissue sample is taken from the lining of the small intestine and examined under a microscope. The presence of specific changes, such as villous atrophy and increased intraepithelial lymphocytes, can confirm the diagnosis of celiac disease.

It's important to note that for accurate test results, it is recommended that individuals continue to consume gluten-containing foods in their diet before undergoing testing. This is because going on a gluten-free diet prior to testing can lead to false-negative results.

If the initial tests suggest celiac disease, a healthcare provider may recommend a gluten-free diet trial. If symptoms improve on a gluten-free diet and reappear upon gluten reintroduction, it further supports the diagnosis of celiac disease.

Diagnosing celiac disease involves a combination of clinical evaluation, serology tests, genetic testing, and intestinal biopsy. It's essential to consult with a healthcare professional who can guide you through the diagnostic process and interpret the test results accurately.